A close friend said Wilson - who also appeared in the TV series The Parkers and the movies House Party 2 and 3 - died of cervical cancer.
Wilson's cancer returned recently after several years in remission, said Jeffrey Pittle.
Pittle made the announcement on a website he had set up to raise funds for Wilson's treatment.
"It is with a heavy heart that I can verify that Yvette passed away last evening after a lengthy and hard battle," he said.
"She was a fighter to the end, and her talent, humour and amazing friendship will be sorely missed. She will live on through her awesome body of work."
The actress had undergone a kidney transplant before the return of her cancer.
Her co-star across a number of series, Brandy Norwood, paid respects to the actress on Twitter, writing 'So saddened by the loss of Yvette Wilson. She was such a beautiful spirit. May she rest in peace.'
Wilson's Moesha co-star Shar Jackson said on Twitter: "Oh god...My heart is soooo unbelievably broken," adding later: "I wanna thank all my tweeties for their prayers but god has chosen to take my sister Yvette home...".
Ray actor Jamie Foxx tweeted: "God bless u Yvette Wilson. Tears in my eyes. Keep God laughing."
Fugees singer Lauryn Hill wrote her on website: "R.I.P Yvette Wilson (Andell From The Parkers). She recently lost her battle with cancer. Life is short, so cherish yours."
Wilson was born in Los Angeles and began her career as a stand-up comedian.
tags: yvette wilson died, cancer, moesha, andell, parker
Actress Yvette Wilson dies from cancer aged 48 Reviewed by afree on 5:05 PM Rating: